Leukopoiesis Model
# Eqn 1:
#β(Q) is the introduction rate
#β0 represents the maximal rate of introduction in the proliferating phase
#θ1 is the value for which β reaches half of its maximal value
#n is the sen- sitivity of the rate of reintroduction
#Q is the quiscent cells
# Eqn 2:
#k(W) is the differentiation rate
#k0 is a proportionality coefficiet
#m and θ2 depend on the growth factors responsible for maturation of considered white blood cells
#W is lymphocytes (T, B, or NK)
# Eqn 3:
#Kv is the differentiation rate to other blood cells
#γ1 is the apoptosis rate for prolif. haematopoietic stem cells
#τ1 is the proliferation phase duration
# Eqn 4:
#A is the amplification parameter
#γ2 is the death rate of matured blood cells
#τ2 is the amplification phase duration
B-Cell
Modeling B-Cell reporductions where:
β0 =1.77 day−1,θ1 =1×108 cells/kg,n =3 , τ1 =0.05 day,γ1 =0.1day−1
k0 =0.1day−1,θ2 =1×108 cells/kg,m =2 , τ2 =2day,K =0.02 day−1,A =20 .
No animations available.
No state variables defined.
No parameters defined.
Download Source File (leukopoiesis.ode)
The source code file can be used with XPP/XPPAUT or other simulation tools.
- Marcus Snell, Arizona State University
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